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KMID : 0370220110550040295
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Yakhak Hoeji
2011 Volume.55 No. 4 p.295 ~ p.300
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Anti-allergic Activity of Butanol Fraction of Asterias amurensis
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Yang Ju-Hye
Na Min-Kyun
Chang Hyun-Wook
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Abstract
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We investigated the effects of butanol fraction of Asterias amurensis (BFA) on the anti-allergic activity. BFA inhibited both cyclooxygenase-2 dependent prostaglandin D₂ and 5-lipoxygenase dependent leukotriene C₄ generation in a concentration-dependent manner with IC50 values of 174.6 and 22.2 ㎍/ml, respectively. In addition, BFA also inhibited the degranulation in a dose dependent manner. Furthermore, oral administration of BFA inhibited IgE-mediated passive cutaneous anaphylaxis in mice. These results suggested that BFA may be useful in regulating mast cell-mediated allergic diseases.
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KEYWORD
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Asterias amurensis, mouse bone marrow-derived mast cells, cyclooxygenase-2, 5-lipoxygenase, anti-allergic effect
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